2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W492795
    Quifenadine hydrochloride 10447-38-8 98%
    Quifenadine hydrochloride is an H1-histamine receptor blocker and can be used in the research of anti-arrhythmia.
    Quifenadine hydrochloride
  • HY-W587945
    (E)-3-Feruloylquinic acid 87099-72-7 98%
    (E)-3-Feruloylquinic acid (Compound 3) is a chlorogenic acid. (E)-3-Feruloylquinic acid can be isolated from the aerial parts of Tetrastigma hemsleyanum. (E)-3-Feruloylquinic acid inhibits soluble epoxide hydrolase (sEH) with an IC50 of 60.7 μM. (E)-3-Feruloylquinic acid can be used in the study of vascular system diseases.
    (E)-3-Feruloylquinic acid
  • HY-W595136
    (rac)-α-Carotene 432-70-2 98%
    (rac)-α-Carotene is the racemate of α-Carotene. α-Carotene is a carotenoid and potent antioxidant. Serum α-Carotene concentrations are inversely associated with the risk of all-cause mortality, cardiovascular disease, cancer, and mortality from all causes other than cardiovascular disease and cancer.
    (rac)-α-Carotene
  • HY-W650803
    Nemazoline 130759-56-7 98%
    Nemazoline (A-57219) is selective α-adrenergic agent with α1-agonist/α2-antagonist activity, which is used as a nasal decongestant. Nemazoline produces decongestion by α1-mediated contraction of capacitance vessels, but not compromises blood flow by virtue of α2-antagonism. Nemazoline also blocks endogenous noradrenaline-mediated α 2-constriction of the resistance vessels.
    Nemazoline
  • HY-W653969
    Arotinolol-d5 hydrochloride 2514848-16-7 98%
    Arotinolol-d5 (hydrochloride) is deuterium labeled Arotinolol. Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol also shows potency for inhibiting the binding of the radioligand 125I-ICYP to 5HT1B-serotonergic receptor sites. Arotinolol is an antihypertensive agent for the treatment of a variety of cardiovascular pathologies as well as non-cardiovascular diseases.
    Arotinolol-d5 hydrochloride
  • HY-W654000
    Cyclic GMP-13C,15N2 98%
    Cyclic GMP-13C,15N2 is 13C and 15N labeled Cyclic GMP (HY-113469). Cyclic GMP (cGMP), an important second messenger, is a major intracellular mediator of extracellular signals such as nitric oxide (NO) and natriuretic peptides (NPs). Effects of Cyclic GMP occur through three main groups of cellular targets: cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and PDEs. Cyclic GMP can inhibit both platelet adhesion and aggregation. cGAMP (Cyclic-GMP-AMP) (HY-12512), a conjugate of Cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses.
    Cyclic GMP-13C,15N2
  • HY-W674245
    10-Hydroxyhexadecanoic acid 23048-75-1 98%
    10-Hydroxyhexadecanoic acid is a hydroxy fatty acid found in Camembert cheese. 10-Hydroxyhexadecanoic acid can promote cholesterol efflux from ABCA1 and ABCG1, preventing the accumulation of excess cholesterol in cells. 10-Hydroxyhexadecanoic acid can be used in anti-atherosclerosis research.
    10-Hydroxyhexadecanoic acid
  • HY-W686186
    Prasugrel hydroxy thiolactone 947502-66-1 98%
    Prasugrel hydroxy thiolactone (compound M18) is a metabolite of Prasugrel (HY-15284). Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits Adenosine 5'-diphosphate (ADP, HY-W010918)-induced platelet aggregation.
    Prasugrel hydroxy thiolactone
  • HY-W699526
    Dimebutic acid-d6 101419-75-4 98%
    Dimebutic acid-d6 (NSC-16045-d6; NSC-741804-d6) is the deuterium labeled Dimebutic acid (HY-W015881). Dimebutic acid is a fatty acid derivative. Dimebutic acid is an orally active short-chain fatty acid. Dimebutic acid stimulates fetal globin production and alters the balance of Bcl family proteins. Dimebutic acid prolongs red blood cell survival. Dimebutic acid exhibits toxicity in rats. Dimebutic acid is used in the study of β-thalassemia and sickle cell disease.
    Dimebutic acid-d6
  • HY-W699829
    (3R,5R)-Rosuvastatin Lactone-d6 98%
    (3R,5R)-Rosuvastatin Lactone-d6 is the deuterium labeled (3R,5R)-Rosuvastatin Lactone (HY-135406). (3R,5R)-Rosuvastatin Lactone is an isomer of Rosuvastatin Lactone.
    (3R,5R)-Rosuvastatin Lactone-d6
  • HY-W701743
    3,4-Dihydroxyamphetamine hydrochloride 828-06-8 98%
    3,4-Dihydroxyamphetamine (α-Methyldopamine) (hydrochloride) is a secondary metabolite of 3,4-Methylenedioxymethamphetamine (MDMA). 3, 4-dihydroxyamphetamine (hydrochloride) is cytotoxic to rat hepatocytes. 3, 4-dihydroxyamphetamine (hydrochloride) is also used in the study of high blood pressure.
    3,4-Dihydroxyamphetamine hydrochloride
  • HY-W703688
    Guanoxani sulfate 5714-04-5 98%
    Guanoxani sulfate (NSC 108162) is an antihypertensive drug.
    Guanoxani sulfate
  • HY-W704079
    1-Stearoyl-sn-glycerol 22610-61-3 98.66%
    1-Stearoyl-sn-glycerol is (MG(18:0/0:0/0:0); L-(+)-1-Monostearin; 1-Octadecanoyl-sn-glycerol) is a monoglyceride and also a metabolite found in plasma, which can be used in metabolomic analysis of plasma for coronary artery lesions (CAL).
    1-Stearoyl-sn-glycerol
  • HY-W705434
    Dabigatran etexilate-d11 2469006-94-6 98%
    Dabigatran etexilate-d11 (BIBR 1048-d11) is the deuterium labeled Dabigatran etexilate (HY-10274). Dabigatran etexilate (BIBR 1048) is an orally active proagent of Dabigatran (a direct inhibitor of thrombin). Dabigatran etexilate has anticoagulant effects and is used for the prophylaxis of venousthromboembolism and stroke due to atrial fibrillation.
    Dabigatran etexilate-d11
  • HY-W705539
    DL-Phenylephrine-d3 hydrochloride 2714485-34-2 98%
    DL-Phenylephrine-d3 hydrochloride ((±)-Phenylephrine-d3 hydrochloride) is the deuterium labeled DL-Phenylephrine hydrochloride (HY-W014726). DL-Phenylephrine ((±)-Phenylephrine) hydrochloride is a selective agonist of the alpha1-adrenergic receptor, exhibiting potent vasoconstrictive activity.
    DL-Phenylephrine-d3 hydrochloride
  • HY-W705705
    NIP 142 203002-58-8 98%
    NIP-142 is a benzopyran derivative with multiple ion channel-blocking effects. NIP-142 selectively blocks the potassium ion channels enriched in atrial muscle, prolonging the effective refractory period (ERP) and action potential duration (APD) of the atrium, while having minimal effect on ventricular repolarization. NIP-142 also inhibits L-type/T-type calcium channels and sodium channels, further contributing to its anti-arrhythmic effect. NIP-142 shows significant efficacy in various atrial fibrillation models. NIP-142 can be used for research on arrhythmias.
    NIP 142
  • HY-W707407
    Bisoprolol-d7 1310012-16-8 98%
    Bisoprolol-d7 is deuterium labeled Bisoprolol. Bisoprolol is a potent, selective and orally active β1-adrenergic receptor blocker with little activity on β2-receptor. Bisoprolol has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research.
    Bisoprolol-d7
  • HY-W707554
    Ticlopidine hydrochloride-d6 2985259-58-1 98%
    Ticlopidine hydrochloride-d6 is the deuterium labeled Ticlopidine hydrochloride (HY-B0153A). 0
    Ticlopidine hydrochloride-d6
  • HY-W707656
    Aspirin-d7 98%
    Aspirin-d7 is the deuterium labeled Aspirin (HY-14654). Aspirin (Acetylsalicylic acid) is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2, with IC50 values of 5 and 210 μg/mL, respectively. Aspirin induces apoptosis. Aspirin inhibits the activation of NF-κB. Aspirin also inhibits platelet prostaglandin synthetase, and can prevent coronary artery and cerebrovascular thrombosis.
    Aspirin-d7
  • HY-W710337
    Colterol hydrochloride-d9 2714484-83-8 98%
    Colterol hydrochloride-d9 is the deuterium labeled Colterol hydrochloride (HY-128510A). Colterol hydrochloride is the hydrochloride salt form of Colterol (HY-128510). Colterol hydrochloride is the agonist for adrenergic receptor, and exhibits good affinity to β1-adrenoreceptor (heart) and β2-adrenoreceptor (lung) with IC50 of 645 nM and 147 nM. Colterol hydrochloride exhibits potential as a bronchodilator.
    Colterol hydrochloride-d9
Cat. No. Product Name / Synonyms Application Reactivity